Hematopoietic Stem Cell Defense Mechanisms

WARNING - The Passegué Lab has now left UCSF and relocated to Columbia University Medical Center (CUMC) in New York city

Dr. Passegué has joined the Department of Genetics and Development and taken the direction of the Columbia Stem Cell Initiative (CUMC). Her laboratory is located on the 7th floor of the Hammer Health Sciences Center (HHSC) building, rooms 724 and 726, at 701 West 168th Street New York, NY 10032, USA. Dr. Passegué can be reached by email (ep2828@cumc.columbia.ediu) or via her executive assistant Lalena Luna (ll3129@cumc.columbia.edu) and lab manager Gloria Perez (gp2499@cumc.columbia.edu).

A new website is currently under development and will be available soon

 

 

Our research focuses on understanding the general defense mechanisms used by hematopoietic stem cells (HSC) to protect blood production during the lifetime of an ever-changing organism. This fundamental question is central to tissue maintenance and regeneration, and has implications for every aspect of adult physiology ranging from response to stress, development of diseases and biology of aging. Our laboratory is interested in identifying the mechanisms controlling HSC activity in normal and stress conditions, and in understanding how they are affected during disease development and in physiological aging. Our goal is to identify affected genes and pathways that could be used to develop new therapies to treat human diseases and help combat aging. Current projects investigate the role of apoptosis, autophagy, immune regulations, DNA repair mechanisms and changes in the bone marrow niche in HSC function.