“I believe that stem cell and cancer biology intersect to produce information that is invaluable to both fields and to the treatment of human diseases”
E. Passegué

Normal and Leukemic Hematopoiesis

The goal of our research is to decipher the cellular and molecular mechanisms governing normal blood function and to unravel how they become deregulated in myeloid malignancies using the mouse as a model system. We are particularly interested in understanding how normal hematopoietic stem cells (HSCs) can become leukemia-initiating stem cells (LCSs), which promote tumor growth and disease recurrence, and to search for ways to prevent their transformation. Current projects in the laboratory study the implication of apoptosis, autophagy, immune regulation, DNA repair mechanisms and differentiation pathways in the maintenance and regulation of normal HSCs and tranformed LSCs.