Publications

2015

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.                                                                                                                                                                                                                                                                                                                        Wong JC, Weinfurtner KM, Alzamora MD, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K., Elife. 2015 Jul 20;4. doi: 10.7554/eLife.07839.

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.                                                                                                                                                                                                                                                                                                        Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B, Passegué E.Cell Stem Cell. 2015 Jul 2;17(1):35-46. doi: 10.1016/j.stem.2015.05.003. Epub 2015 Jun 18.

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.                                                                                                                                                                                                                                                                                                                          Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC., Haematologica. 2015 Aug;100(8):1064-1075. Epub 2015 Jun 18.

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.                                                                                                                                                                                                                                                                                                                                                                               Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M., Nat Commun. 2015 Mar 10;6:6471. doi: 10.1038/ncomms7471.

Normal and leukemic stem cell niches: insights and therapeutic opportunities.

Schepers K, Campbell TB, Passegué E. - Cell Stem Cell. 2015 Mar 5;16(3):254-67

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.

Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. - Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75.

2014

Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.

Mirantes C, Passegué E, Pietras EM. - Exp Cell Res. 2014 Dec 10;329(2):248-54.

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E. - Nature. 2014 Aug 14;512(7513):198-202.

Surviving change: the metabolic journey of hematopoietic stem cells.

Kohli L, Passegué E. - Trends Cell Biol. 2014 Aug; 24(8):479-87.

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

Pietras EM, Lakshminarasimhan R, Techner JM, Fong S, Flach J, Binnewies M, Passegué E. - J Exp Med. 2014 Feb 10; 211(2):245-62.

2013

Resilient and resourceful: Genome maintenance strategies in hematopoietic stem cells.

Bakker ST, Passegué E. - Exp Hematol. 2013 Nov; 41(11):915-23.

Linking HSCs to their youth.

Pietras EM, Passegué E. - Nat Cell Biol. 2013 Aug; 15(8):885-7.

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E.z - Cell Stem Cell. 2013 Sep 5; 13(3):285-99.

Born to survive: autophagy in hematopoietic stem cell maintenance.

Warr MR, Kohli L, Passegué E. - Cell Cycle. 2013 Jul 1; 12(13):1979-80.

Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.

Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC. - Leukemia. 2013 Jul; 27(7):1570-3.

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. - Nature. 2013 Feb 21; 494(7437):323-7.

Metabolic makeover for HSCs.

Warr MR, Passegué E. - Cell Stem Cell. 2013 Jan 3; 12(1):1-3.

2012

Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.

Schepers K, Hsiao EC, Garg T, Scott MJ, Passegué E. - Blood. 2012 Oct 25; 120(17):3425-35.

Stem cells assessed.

Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. - Nat Rev Mol Cell Biol. 2012 Jul; 13(7):471-6.

Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations.

Smith-Berdan S, Schepers K, Ly A, Passegué E, Forsberg EC. - Cell Cycle. 2012 Feb 15; 11(4):675-82.

Cell cycle regulation in hematopoietic stem cells.

Pietras EM, Warr MR, Passegué E. - J Cell Biol. 2011 Nov 28; 195(5):709-20.

IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development.

Reynaud D, Pietras E, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E. - Cancer Cell. 2011 Nov 15; 20(5):661-73.

Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI. - Genes Dev. 2011 Aug 15; 25(16):1746-57.

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies.

Warr MR, Pietras EM, Passegué E. - Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):681-701.

DNA-damage response in tissue-specific and cancer stem cells.

Blanpain C, Mohrin M, Sotiropoulou PA, Passegué E. - Cell Stem Cell. 2011 Jan 7; 8(1):16-29.

On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.

Elefanty AG, Blelloch R, Passegué E, Wernig M, Mummery CL. - Cell Stem Cell. 2010 Oct 8; 7(4):443-50.

PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.

Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. - Cancer Res. 2010 Nov 1; 70(21):8792-801.

The transcription factor Srf regulates hematopoietic stem cell adhesion.

Ragu C, Elain G, Mylonas E, Ottolenghi C, Cagnard N, Daegelen D, Passegué E, Vainchenker W, Bernard OA, Penard-Lacronique V. - Blood. 2010 Nov 25; 116(22):4464-73.

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis.

Mohrin M, Bourke E, Alexander D, Warr MR, Barry-Holson K, Le Beau MM, Morrison CG, Passegué E. - Cell Stem Cell. 2010 Aug 6;7(2):174-85.

Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.

Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL. PLoS One. 2010 Jan 20;5(1):e8785.

IFN-alpha wakes up sleeping hematopoietic stem cells.

Passegué E, Ernst P. - Nat Med. 2009 Jun;15(6):612-3.

JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. - Cancer Cell. 2009 Apr 7;15(4):341-52.