Lab Profile

Masayuki Yamashita

I am from Tokyo, Japan, where I obtained an MD at the University of Tokyo in 2008. After that I worked as a resident at Musashino Red Cross Hospital for two years. During my residency, I saw a lot of patients suffering from incurable hematological malignancies despite intensive therapies, which made me feel the need of a better therapeutic approach based on a deep understanding of how and why leukemia arises from normal hematopoietic cells. Then I pursued a PhD in the laboratory of Dr. Toshio Suda where I studied the role of intrinsic p53-dependent apoptosis pathway in hematopoietic stem cell (HSC) maintenance and development of malignant disease using genetically engineered mice. I joined the Passegué lab in April 2015 where I am studying the role of extrinsic death receptor pathway in HSC and committed progenitor cell survival in the context of normal, stress and malignant hematopoiesis. I like swimming, playing Japanese chess and going outside with my family.